The impact of argan oil on plasma lipids in humans: Systematic review and meta-analysis of randomized controlled trials


Sorin Ursoniu | Amirhossein Sahebkar | Maria-Corina Serban | Maciej Banach | Lipid and Blood Pressure Meta-analysis Collaboration Group

First published:  12 November 2017 |


The study aims to investigate the effect of argan oil on plasma lipid concentrations through a systematic review of the literature and a meta-analysis of available randomized controlled trials. Randomized controlled trials that investigated the impact of at least 2 weeks of supplementation with argan oil on plasma/serum concentrations of at least 1 of the main lipid parameters were eligible for inclusion. Effect size was expressed as the weighted mean difference (WMD) and 95% confidence interval (95% CI). Meta-analysis of data from 5 eligible trials with 292 participants showed a significant reduction in plasma concentrations of total cholesterol (WMD: −16.85 mg/dl, 95% CI [−25.10, −8.60], p < .001), low-density lipoprotein cholesterol (WMD: −11.67 mg/dl, 95% CI [−17.32, −6.01], p < .001), and triglycerides (WMD: −13.69 mg/dl, 95% CI [−25.80, −1.58], p = .027) after supplementation with argan oil compared with control treatment, and plasma concentrations of high-density lipoprotein cholesterol (WMD: 4.14 mg/dl, 95% CI [0.86, 7.41], p = .013) were found to be increased. Argan oil supplementation reduces total cholesterol, low-density lipoprotein cholesterol, and triglycerides and increases high-density lipoprotein cholesterol levels. Additionally, larger clinical trials are needed to assess the impact of argan oil supplementation on other indices of cardiometabolic risk and on the risk of cardiovascular outcomes.

  1. Banach, M.Aronow, W. S.Serban, C.Sahabkar, A.Rysz, J.Voroneanu, L., & Covic, A. (2015). Lipids, blood pressure and kidney update 2014Pharmacological research : The official journal of the Italian Pharmacological Society95-96C111125.
  2. Berrougui, H.Cloutier, M.Isabelle, M., & Khalil, A. (2006). Phenolic-extract from argan oil (Argania spinosa L.) inhibits human low-density lipoprotein (LDL) oxidation and enhances cholesterol efflux from human THP-1 macrophagesAtherosclerosis184(2), 389396.
  3. Bester, D.Esterhuyse, A. J.Truter, E. J., & van Rooyen, J. (2010). Cardiovascular effects of edible oils: A comparison between four popular edible oilsNutrition Research Reviews23(2), 334348.
  4. Borenstein, M.Hedges, L.Higgins, J., & Rothstein, H. (2005). Comprehensive meta-analysis version 2Englewood, NJ: Biostat104
  5. Charrouf, Z., & Guillaume, D. (2008). Argan oil: Occurrence, composition and impact on human healthEuropean Journal of Lipid Science and Technology110(7), 632636.
  6. Cherki, M.Berrougui, H.Drissi, A.Adlouni, A., & Khalil, A. (2006). Argan oil: Which benefits on cardiovascular diseases? Pharmacological Research54(1), 15.
  7. Cherki, M.Derouiche, A.Drissi, A.El Messal, M.Bamou, Y.Idrissi-Ouadghiri, A., … Adlouni, A. (2005). Consumption of argan oil may have an antiatherogenic effect by improving paraoxonase activities and antioxidant status: Intervention study in healthy menNutrition, metabolism, and cardiovascular diseases : NMCD15(5), 352360.
  8. Cicero, A. F. G.Colletti, A.Bajraktari, G.Descamps, O.Djuric, D. M.Ezhov, M., … Banach, M. (2017). Lipid-lowering nutraceuticals in clinical practice: Position paper from an International Lipid Expert PanelNutrition Reviews75(9), 731767.
  9. Dakiche, H.Khali, M., & Boutoumi, H. (2017). Phytochemical Characterizationand in vivo anti-inflammatory and wound-healing activities of Argania spinosa (L.) Skeels seed oilRecords of Natural Products11(2), 171.
  10. Derouiche, A.Cherki, M.Drissi, A.Bamou, Y.El Messal, M.Idrissi-Oudghiri, A., … Adlouni, A. (2005). Nutritional intervention study with argan oil in man: Effects on lipids and apolipoproteinsAnnals of Nutrition & Metabolism49(3), 196201.
  11. El Abbassi, A.Khalid, N.Zbakh, H., & Ahmad, A. (2014). Physicochemical characteristics, nutritional properties, and health benefits of argan oil: A reviewCritical Reviews in Food Science and Nutrition54(11), 14011414.
  12. El Kebbaj, R.Andreoletti, P.El Hajj, H. I.El Kharrassi, Y.Vamecq, J.Mandard, S., … Cherkaoui-Malki, M. (2015). Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1α, (PGC-1α), peroxisome proliferator-activated receptor α (PPARα) and estrogen related receptor α (ERRα)Biochimie Open15159.
  13. Eljaoudi, R.Elkabbaj, D.Bahadi, A.Ibrahimi, A.Benyahia, M., & Errasfa, M. (2015). Consumption of Argan oil improves anti-oxidant and lipid status in hemodialysis patientsPhytotherapy research : PTR29(10), 15951599.
  14. Errouane, K.Doulbeau, S.Vaissayre, V.Leblanc, O.Collin, M.Kaid-Harche, M., & Dussert, S. (2015). The embryo and the endosperm contribute equally to argan seed oil yield but confer distinct lipid features to argan oilFood Chemistry181270276.
  15. Guillaume, D., & Charrouf, Z. (2011). Argan oil monographAlternative medicine review : a journal of clinical therapeutic16(3), 275279.
  16. Haimeur, A.Messaouri, H.Ulmann, L.Mimouni, V.Masrar, A.Chraibi, A., … Meskini, N. (2013). Argan oil prevents prothrombotic complications by lowering lipid levels and platelet aggregation, enhancing oxidative status in dyslipidemic patients from the area of Rabat (Morocco)Lipids in Health and Disease12107.
  17. Khallouki, F.Younos, C.Soulimani, R.Oster, T.Charrouf, Z.Spiegelhalder, B., … Owen, R. W. (2003). Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effectsEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)12(1), 6775.
  18. Marfil, R.Giménez, R.Martínez, O.Bouzas, P. R.Rufián-Henares, J. A.Mesías, M., & Cabrera-Vique, C. (2011). Determination of polyphenols, tocopherols, and antioxidant capacity in virgin argan oil (Argania spinosa, Skeels)European Journal of Lipid Science and Technology113(7), 886893.
  19. Moher, DLiberati, ATetzlaff, JAltman, DG2009Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statementPLoS Medicine, 6(7): e1000097.
  20. Monfalouti, H. E.Guillaume, D.Denhez, C., & Charrouf, Z. (2010). Therapeutic potential of argan oil: A reviewThe Journal of Pharmacy and Pharmacology62(12), 16691675.
  21. Nardini, M.D’Aquino, M.Tomassi, G.Gentili, V.Di Felice, M., & Scaccini, C. (1995). Inhibition of human low-density lipoprotein oxidation by caffeic acid and other hydroxycinnamic acid derivativesFree Radical Biology & Medicine19(5), 541552.
  22. Ould Mohamedou, M. M.Zouirech, K.El Messal, M.El Kebbaj, M. S.Chraibi, A., & Adlouni, A. (2011). Argan oil exerts an antiatherogenic effect by improving lipids and susceptibility of LDL to oxidation in type 2 diabetes patientsInternational Journal of Endocrinology2011747835.
  23. Reaven, P. D.Khouw, A.Beltz, W. F.Parthasarathy, S., & Witztum, J. L. (1993). Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by beta-caroteneArteriosclerosis and thrombosis : a journal of vascular biology13(4), 590600.
  24. Rueda, A.Cantarero, S.Seiquer, I.Cabrera-Vique, C., & Olalla, M. (2017). Bioaccessibility of individual phenolic compounds in extra virgin argan oil after simulated gastrointestinal processLWT – Food Science and Technology75466472.
  25. Sahebkar, A.Chew, G. T., & Watts, G. F. (2014). Recent advances in pharmacotherapy for hypertriglyceridemiaProgress in Lipid Research564766.
  26. Sahebkar, A., & Watts, G. F. (2013). New LDL-cholesterol lowering therapies: Pharmacology, clinical trials, and relevance to acute coronary syndromesClinical Therapeutics35(8), 10821098.
  27. Santini, A., & Novellino, E. (2017). Nutraceuticals in hypercholesterolaemia: An overviewBritish Journal of Pharmacology174(11), 14501463.
  28. Seiquer, I.Rueda, A.Olalla, M., & Cabrera-Vique, C. (2015). Assessing the bioavailability of polyphenols and antioxidant properties of extra virgin argan oil by simulated digestion and Caco-2 cell assays. Comparative study with extra virgin olive oilFood Chemistry188496503.
  29. Sour, S.Belarbi, M.Khaldi, D.Benmansour, N.Sari, N.Nani, A., … Visioli, F. (2012). Argan oil improves surrogate markers of CVD in humansThe British Journal of Nutrition107(12), 18001805.
  30. Terés, S.Barceló-Coblijn, G.Benet, M.Álvarez, R.Bressani, R.Halver, J. E., & Escribá, P. V. (2008). Oleic acid content is responsible for the reduction in blood pressure induced by olive oilProceedings of the National Academy of Sciences105(37), 1381113816.