Lipoprotein(a) Levels in Patients With Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis

Authors:

Kazuhiko Kotani, MD, PhD | Amirhossein Sahebkar, PharmD | Maria-Corina Serban, MD, PhD | Sorin Ursoniu, MD, PhD | Dimitri P. Mikhailidis, BSc, MSc, MD | Giovanni Mariscalco, MD, PhD | Steven R. Jones, MD | Seth Martin, MD | Michael J. Blaha, MD | Peter P. Toth, MD | Manfredi Rizzo, MD, PhD | Karam Kostner, MD, PhD | Jacek Rysz, MD, PhD | Maciej Banach, MD, PhD, FNLA, FAHA, FESC, FASA | Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
First published:  September 29, 2016 | https://doi.org/10.1177/0003319716637792

Abstract:

Circulating markers relevant to the development of abdominal aortic aneurysm (AAA) are currently required. Lipoprotein(a), Lp(a), is considered a candidate marker associated with the presence of AAA. The present meta-analysis aimed to evaluate the association between circulating Lp(a) levels and the presence of AAA. The PubMed-based search was conducted up to April 30, 2015, to identify the studies focusing on Lp(a) levels in patients with AAA and controls. Quantitative data synthesis was performed using a random effects model, with standardized mean difference (SMD) and 95% confidence interval (CI) as summary statistics. Overall, 9 studies were identified. After a combined analysis, patients with AAA were found to have a significantly higher level of Lp(a) compared to the controls (SMD: 0.87, 95% CI: 0.41-1.33, P < .001). This result remained robust in the sensitivity analysis, and its significance was not influenced after omitting each of the included studies from the meta-analysis. The present meta-analysis confirmed a higher level of circulating Lp(a) in patients with AAA compared to controls. High Lp(a) levels can be associated with the presence of AAA, and Lp(a) may be a marker in screening for AAA. Further studies are needed to establish the clinical utility of measuring Lp(a) in the prevention and management of AAA.

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