Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms

Authors:

Piotr Chruściel | Amirhossein Sahebkar | Magdalena Rembek-Wieliczko | Maria-Corina Serban | Sorin Ursoniu | Dimitri P. Mikhailidis | Steven R. Jones | Svetlana Mosteoru | Michael J. Blaha | Seth S. Martin | Jacek Rysz | Peter P. Toth | Gregory Y.H. Lip | Michael J. Pencina | Kausik K. Ray | Maciej Banach | Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
First published: July 14, 2016 | https://doi.org/10.1016/j.atherosclerosis.2016.07.897

Abstract:

Background and aims

The effect of statin therapy on plasma adiponectin levels has not been conclusively studied. Therefore, we aimed to evaluate this effect through a systematic review and meta-analysis of available randomized controlled trials (RCTs).

Methods

Quantitative data synthesis was performed using a random-effects model with weighted mean difference (WMD) and 95% confidence interval (CI) as summary statistics.

Results

In 30 studies (43 study arms) with 2953 participants, a significant increase in plasma adiponectin levels was observed after statin therapy (WMD: 0.57 μg/mL, 95% CI: 0.18, 0.95, p = 0.004). In subgroup analysis, atorvastatin, simvastatin, rosuvastatin, pravastatin and pitavastatin were found to change plasma adiponectin concentrations by 0.70 μg/mL (95% CI: −0.26, 1.65), 0.50 μg/mL (95% CI: −0.44, 1.45), −0.70 μg/mL (95% CI: −1.08, −0.33), 0.62 μg/mL (95% CI: −0.12, 1.35), and 0.51 μg/mL (95% CI: 0.30, 0.72), respectively. With respect to duration of treatment, there was a significant increase in the subset of trials lasting ≥12 weeks (WMD: 0.88 μg/mL, 95% CI: 0.19, 1.57, p = 0.012) but not in the subset of <12 weeks of duration (WMD: 0.18 μg/mL, 95% CI: −0.23, 0.58, p = 0.390). Random-effects meta-regression suggested a significant association between statin-induced elevation of plasma adiponectin and changes in plasma low density lipoprotein cholesterol levels (slope: 0.04; 95% CI: 0.01, 0.06; p = 0.002).

Conclusions

The meta-analysis showed a significant increase in plasma adiponectin levels following statin therapy. Although statins are known to increase the risk for new onset diabetes mellitus, our data might suggest that the mechanism for this is unlikely to be due to a reduction in adiponectin expression.

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Conflict of interest

This meta-analysis was written independently; no company or institution supported it financially. Some of the authors have given talks, attended conferences and participated in trials and advisory boards sponsored by various pharmaceutical companies.

Author contributions

AS designed the study, made the statistical analysis, corrected the draft of the paper; PC, MR, CS made the literature search, drafted the manuscript; MB designed the study, made the literature search, drafted the manuscript, prepared the final version, submitted the paper; SU made the literature search, drafted the manuscript; DPM, SRJ, SM, MJB, SSM, JR, PPT, GYHL, MJP, KKRcorrected the draft of the paper and prepared the final version of the manuscript. All authors read and approved the final manuscript.

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