CONCLUSION: PCSK9 targeted therapies appear to reduce the risk of stroke; however, no significant association was observed for the risk of dementia and Parkinson's disease.
Exosomes represent a promising class of naturally produced nanoparticles that exist at the nanoscale and carry a negative surface charge under physiological conditions. These tiny membranebound vesicles are released by cells throughout the body and function as biological messengers, transporting various molecular cargos between cells and facilitating critical cell-to-cell communication pathways. Existing therapies for neurodegenerative […]
Life expectancy is a key indicator of population health and an important guide for health policy^(1,2). Although Asia represents approximately 60% of the global population, studies of longitudinal trends in life expectancy and their underlying drivers across Asian countries remain limited, with most previous research focused on western or high-income settings^(3-6). Here we provide a […]
CONCLUSIONS: Major CV risk algorithms classify Indian AMI patients very differently, with substantial potential for misclassification. Although PREVENT and FRS showed nearly similar classification of high risk, 80% of patients were still not identified as high risk before their event, underscoring the need for South Asia-specific risk score development and validation and alternative preventive strategies.
Emergency laparotomies carry profound physiological morbidity, yet the adoption of minimally invasive surgery (MIS) in acute care remains hindered by laparoscopic limitations. While robotic platforms offer 3D visualization and wristed articulation to overcome these barriers, their application in emergency general surgery (EGS) and visceral trauma remains controversial. This systematic review aims to define the clinical […]
Type 2 diabetes mellitus (T2DM) involves progressive muscle wasting, metabolic dysregulation in peripheral tissues, chronic hyperglycemia, and insulin resistance. Momordica charantia is an antidiabetic agent often limited by bitterness. To improve palatability and efficacy, we developed EMS by combining M. charantia and Stevia rebaudiana (9:1). EMS's antidiabetic effects were tested in streptozotocin (STZ)-induced and genetic […]
DNA methylation, a conserved epigenetic modification, influences several crucial functions, including gene expression, silencing of transposable elements, genomic stability, and growth and development. While advances in whole-genome bisulfite sequencing enable the identification of numerous DNA methylation sites in plants, their utility depends on characterizing DNA methylation marks for specific traits and applying them effectively in […]
Haemonchus contortus is one of the most economically devastating gastrointestinal nematodes in small ruminants, with escalating anthelmintic resistance threatening sustainable parasitic control. The present study evaluated the in vivo efficacy, safety, and physiological effects of an aqueous whole-plant extract of Swertia chirata against naturally occurring H. contortus infections in Barbari goats under field conditions. Thirty […]
CONCLUSION: The persistent rise in HF-related mortality, especially pronounced among NH Black patients and in specific geographic locales, underscores the need for enhanced collaborative efforts across oncology, cardiology, cardio-oncology, public health, and policy domains to lessen disparities and improve the overall health outcomes of breast cancer survivors.
Beta-amyloid (Aβ) aggregates interact with glial cells, particularly astrocytes, leading to altered morphology, disrupted homeostasis, and ultimately contributing to neurodegeneration in Alzheimer's disease (AD). Astrocytes, once considered passive support cells, are now recognized as active participants in neuroinflammatory and neurodegenerative cascades. Recent research has highlighted profound transcriptomic and metabolomic disturbances in astrocytes under AD pathology, […]
Sargassum filipendula is a widely distributed, edible brown alga that possesses a rich nutritional profile. Several studies have demonstrated that the components/extracts of S. filipendula (SFE) possess diverse pharmacological potential against both infectious and non-infectious diseases. These include antibacterial and antifungal properties, as well as antioxidant, anti-aging, anti-osteoporosis, antiviral, antiprotozoal, and immunomodulatory effects. Furthermore, SFE […]
Background: Melatonin has antioxidant and anti-inflammatory properties that may attenuate ischemia-reperfusion injury, but randomized cardiovascular trial data remain inconsistent. Objectives: This study sought to evaluate the association of melatonin supplementation with cardiovascular outcomes across randomized trials. Methods: We performed a systematic review and meta-analysis of randomized trials comparing melatonin with placebo, usual care, or no […]
CONCLUSION: The findings of this study suggest that Vericiguat, when added to guideline-directed medical therapy in patients with heart failure, was associated with a borderline, non-significant reduction in the risk of the composite outcome of cardiovascular death or heart failure hospitalization, as well as all-cause mortality. Further large-scale randomized trials are warranted to better define […]
We report a combined experimental and theoretical study of the formation and decay dynamics of a ground-state twisted intermediate (TI) involved in the ultrafast internal conversion of UV-excited pyrimidine nucleosides and nucleotides in aqueous solution. Infrared transient absorption spectroscopy identifies a TI featuring a strongly twisted C5=C6 double bond, and its quantum yield (Φ(TI)) and […]
CONCLUSIONS: In this propensity-matched, real-world cohort, IVL was associated with lower mortality and fewer adverse cardiovascular events than atherectomy, with a comparable safety profile. Given the likelihood of residual selection bias, these observational findings require confirmation in randomized trials.
Selective synthesis of geometrical isomers remains a paramount challenge in coordination chemistry with profound implications for development in optoelectronics and catalysis. Herein, we report an operationally simple strategy for the selective synthesis of fac and mer isomers of heteroleptic ruthenium(II) complexes with a general formula [Ru(CN)(N'N')(DMSO)(Cl)]PF(6) from a single common precursor [Ru(CN)(DMSO)(2)(Cl)(2)] by exploiting photoinduced […]
CONCLUSION: Despite a significant rise in all biomarkers, procalcitonin has overall better performance for diagnosing infections. None of the biomarkers could differentiate sepsis at admission.
PURPOSE: Renal trauma constitutes approximately 1% of all trauma cases, yet data on long-term renal function following severe injury remain scarce. This study aimed to evaluate long-term functional and morphological outcomes in patients sustaining Grade 3 or higher renal trauma, and to identify predictors of residual renal function using nuclear imaging. METHODS: This retrospective study […]
CONCLUSIONS: Among adults with diabetes mellitus or obesity undergoing TAVR, GLP-1 RA use was associated with significantly lower risks of several outcomes.
With growing environmental concerns about marine pollution from heavy metals, black soldier fly larvae (BSFL) are gaining attention for their potential use in sustainable waste-to-feed systems. In this study, BSFL were raised on diets containing cadmium (Cd), lead (Pb), mercury (Hg), and arsenic (As) to assess their growth, metal accumulation patterns, and changes in microbiota. […]
Jaiswal V